Circulating tumour cells are associated with histopathological growth patterns of colorectal cancer liver metastases

Tumour-Associated Transcripts and EGFR Deletion Variants in Colorectal Cancer in Primary Tumour, Metastases and Circulating Tumour Cells

The clinical relevance of circulating tumour cells (CTC) in peripheral blood of patients with colorectal cancer (CRC) has been described as an independent prognostic factor useful to monitor drug effects and clinical status. The aim of the present study was to compare the epidermal growth factor receptor (EGFR) status of primary tumour, related metastases and CTC of patients with CRC. Therefore...

Colorectal cancer with synchronous liver metastases.

Managing colorectal cancer liver metastases.

The treatment of resectable colorectal cancer metastases to the liver has undergone changes with the addition of active chemotherapeutic agents, innovations and definition in the surgical procedures, understanding of the benefits and toxicities of the surgical and chemotherapeutic (cytotoxic and biologic) interventions, and use of the team approach. Patients are initially evaluated for the over...

[Value of tumour resection in colorectal cancer with unresectable metastases].

In spite of the lack of scientific evidence, the resection of primary tumors in asymptomatic patients with colorectal cancer (CRC) with unresectable synchronous metastases was a common practice in many centers until the mid-1990s. This method was able to control any possible complications derived from the primary tumor, which occurred in about 20% of patients. Nonetheless, after the implementat...

Histopathological findings in colorectal liver metastases after electrochemotherapy

Electrochemotherapy of colorectal liver metastases has been proven to be feasible, safe and effective in a phase I/II study. In that study, a specific group of patients underwent two-stage operation, and the detailed histopathological evaluation of the resected tumors is presented here. Regressive changes in electrochemotherapy-treated liver metastases were evaluated after the second operation ...